Traditionally subsidized by the Vespucci family, it ended up giving the name to the likely future city of Salvador and the Bahia de Todos los Santos, in Brazil, when he passed Amerigo Vespucci in 1502, precisely the day of All Saints. The Church, begun in 1251, was part of the convent of the Humiliated, an order arrived in Florence from Alexandria in 1239. Around 1310 was placed on the high altar the "Majesty" by Giotto, now in the Uffizi. In the Sacristy are kept other fourteenth-century works, as a "Crucifixion" frescoed by Taddeo Gaddi and the "Cross of Saints" by Giotto (1315). Always goes back to the fourteenth century the slender bell tower. In the fifteenth century, worked here Sandro Botticelli (who is buried in the Church) and Ghirlandaio: painted, respectively, the two frescoes in the apse, today removed and placed at the center of the aisle, "St. Augustine in the study" and "Jerome in the study". In the early seventeenth century, the Franciscan friars did fresco by Jacopo Ligozzi, Giovanni da San Giovanni and other great painters of the cloister with the "Stories of St. Francis". In 1627 the Church was renovated by the architect Sebastiano Pettirossi internally, commissioned by Ferdinando II de 'Medici, with renovations radicals determining current appearance.